PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome

The poly(ADP-ribose) polymerase, PARP1, plays a key role in maintaining genomic integrity by detecting DNA damage and mediating repair. γH2A.X is the primary histone marker for DNA double-strand breaks and PARP1 localizes to H2A.X-enriched chromatin damage sites, but the basis for this association i...

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Detalles Bibliográficos
Autores principales: Sharma, Deepti, De Falco, Louis, Padavattan, Sivaraman, Rao, Chang, Geifman-Shochat, Susana, Liu, Chuan-Fa, Davey, Curt A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917767/
https://www.ncbi.nlm.nih.gov/pubmed/31848352
http://dx.doi.org/10.1038/s41467-019-13641-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917767/
https://www.ncbi.nlm.nih.gov/pubmed/31848352
http://dx.doi.org/10.1038/s41467-019-13641-0

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