Conformational exchange in the potassium channel blocker ShK

ShK is a 35-residue disulfide-linked polypeptide produced by the sea anemone Stichodactyla helianthus, which blocks the potassium channels Kv1.1 and Kv1.3 with pM affinity. An analogue of ShK has been developed that blocks Kv1.3 > 100 times more potently than Kv1.1, and has completed Phase 1b cli...

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Detalles Bibliográficos
Autores principales: Iwakawa, Naoto, Baxter, Nicola J., Wai, Dorothy C. C., Fowler, Nicholas J., Morales, Rodrigo A. V., Sugase, Kenji, Norton, Raymond S., Williamson, Mike P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917819/
https://www.ncbi.nlm.nih.gov/pubmed/31848433
http://dx.doi.org/10.1038/s41598-019-55806-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917819/
https://www.ncbi.nlm.nih.gov/pubmed/31848433
http://dx.doi.org/10.1038/s41598-019-55806-3

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