Pass-back chain extension expands multi-modular assembly line biosynthesis

Modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymatic assembly lines are large and dynamic protein machines that generally effect a linear sequence of catalytic cycles. Here we report the heterologous reconstitution and comprehensive characterization of two hybrid NR...

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Detalles Bibliográficos
Autores principales: Zhang, Jia Jia, Tang, Xiaoyu, Huan, Tao, Ross, Avena C., Moore, Bradley S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917876/
https://www.ncbi.nlm.nih.gov/pubmed/31636431
http://dx.doi.org/10.1038/s41589-019-0385-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917876/
https://www.ncbi.nlm.nih.gov/pubmed/31636431
http://dx.doi.org/10.1038/s41589-019-0385-4

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