Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

The investigational drugs E7820, indisulam and tasisulam (aryl-sulfonamides) promote the degradation of the splicing factor RBM39 in a proteasome-dependent mechanism. While the activity critically depends on the Cullin RING ligase substrate receptor DCAF15, the molecular details remain elusive. Here...

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Detalles Bibliográficos
Autores principales: Faust, Tyler, Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917914/
https://www.ncbi.nlm.nih.gov/pubmed/31686031
http://dx.doi.org/10.1038/s41589-019-0378-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917914/
https://www.ncbi.nlm.nih.gov/pubmed/31686031
http://dx.doi.org/10.1038/s41589-019-0378-3

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