Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling

AIMS: Under hypoxic conditions, nitrite ([Formula: see text]) can be reduced to nitric oxide (NO) eliciting vasorelaxation. However, nitrite also exerts vasorelaxant effects of potential therapeutic relevance under normal physiological conditions via undetermined mechanisms. We, therefore, sought to...

Descripción completa

Detalles Bibliográficos
Autores principales: Feelisch, Martin, Akaike, Takaaki, Griffiths, Kayleigh, Ida, Tomoaki, Prysyazhna, Oleksandra, Goodwin, Joanna J, Gollop, Nicholas D, Fernandez, Bernadette O, Minnion, Magdalena, Cortese-Krott, Miriam M, Borgognone, Alessandra, Hayes, Rosie M, Eaton, Philip, Frenneaux, Michael P, Madhani, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Fast-Track Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918062/
https://www.ncbi.nlm.nih.gov/pubmed/31372656
http://dx.doi.org/10.1093/cvr/cvz202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918062/
https://www.ncbi.nlm.nih.gov/pubmed/31372656
http://dx.doi.org/10.1093/cvr/cvz202

Ejemplares similares