Efficient Intestinal Digestion and On Site Tumor‐Bioactivation are the Two Important Determinants for Chylomicron‐Mediated Lymph‐Targeting Triglyceride‐Mimetic Docetaxel Oral Prodrugs

The oral absorption of chemotherapeutical drugs is restricted by poor solubility and permeability, high first‐pass metabolism, and gastrointestinal toxicity. Intestinal lymphatic transport of lipophilic prodrugs is a promising strategy to improve the oral delivery efficiency of anticancer drugs via...

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Detalles Bibliográficos
Autores principales: Tian, Chutong, Guo, Jingjing, Wang, Gang, Sun, Bingjun, Na, Kexin, Zhang, Xuanbo, Xu, Zhuangyan, Cheng, Maosheng, He, Zhonggui, Sun, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918103/
https://www.ncbi.nlm.nih.gov/pubmed/31871861
http://dx.doi.org/10.1002/advs.201901810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918103/
https://www.ncbi.nlm.nih.gov/pubmed/31871861
http://dx.doi.org/10.1002/advs.201901810

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