Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay

BACKGROUND: Drug efficacy against kelch 13 mutant malaria parasites can be determined in vitro with the ring-stage survival assay (RSA). The conventional assay protocol reflects the exposure profile of dihydroartemisinin. METHODS: Taking into account that other anti-malarial peroxides, such as the s...

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Detalles Bibliográficos
Autores principales: Walz, Annabelle, Leroy, Didier, Andenmatten, Nicole, Mäser, Pascal, Wittlin, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918666/
https://www.ncbi.nlm.nih.gov/pubmed/31849323
http://dx.doi.org/10.1186/s12936-019-3056-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918666/
https://www.ncbi.nlm.nih.gov/pubmed/31849323
http://dx.doi.org/10.1186/s12936-019-3056-8

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