Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice

OBJECTIVES: To examine the ability of takinib, a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor, to reduce the severity of murine type II collagen-induced arthritis (CIA), and to affect function of synovial cells. METHODS: Following the induction of CIA, mice were trea...

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Detalles Bibliográficos
Autores principales: Scarneo, Scott A., Eibschutz, Liesl S., Bendele, Phillip J., Yang, Kelly W., Totzke, Juliane, Hughes, Philip, Fox, David A., Haystead, Timothy A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918687/
https://www.ncbi.nlm.nih.gov/pubmed/31847895
http://dx.doi.org/10.1186/s13075-019-2073-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918687/
https://www.ncbi.nlm.nih.gov/pubmed/31847895
http://dx.doi.org/10.1186/s13075-019-2073-x

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