Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type

BACKGROUND: The lifelong accumulation of somatic mutations underlies age-related phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in a tissue-specific way. Whole genome analyses of somatic mutation patterns, based on both types and genomic distribution of varian...

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Detalles Bibliográficos
Autores principales: Franco, Irene, Helgadottir, Hafdis T., Moggio, Aldo, Larsson, Malin, Vrtačnik, Peter, Johansson, Anna, Norgren, Nina, Lundin, Pär, Mas-Ponte, David, Nordström, Johan, Lundgren, Torbjörn, Stenvinkel, Peter, Wennberg, Lars, Supek, Fran, Eriksson, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918713/
https://www.ncbi.nlm.nih.gov/pubmed/31849330
http://dx.doi.org/10.1186/s13059-019-1892-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918713/
https://www.ncbi.nlm.nih.gov/pubmed/31849330
http://dx.doi.org/10.1186/s13059-019-1892-z

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