NANOG and LIN28 dramatically improve human cell reprogramming by modulating LIN41 and canonical WNT activities

Human cell reprogramming remains extremely inefficient and the underlying mechanisms by different reprogramming factors are elusive. We found that NANOG and LIN28 (NL) synergize to improve OCT4, SOX2, KLF4 and MYC (OSKM)-mediated reprogramming by ∼76-fold and shorten reprogramming latency by at leas...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Ling, Su, Yue, Huang, Chang, Yin, Yexuan, Chu, Alexander, Knupp, Alec, Tang, Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918770/
https://www.ncbi.nlm.nih.gov/pubmed/31806618
http://dx.doi.org/10.1242/bio.047225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918770/
https://www.ncbi.nlm.nih.gov/pubmed/31806618
http://dx.doi.org/10.1242/bio.047225

Ejemplares similares