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Changes in the Stoichiometry of Uniplex Decrease Mitochondrial Calcium Overload and Contribute to Tolerance of Cardiac Ischemia/Reperfusion Injury in Hypothyroidism
Background: Thyroid hormone status in hypothyroidism (HT) downregulates key elements in Ca(2+) handling within the heart, reducing contractility, impairing the basal energetic balance, and increasing the risk of cardiovascular disease. Mitochondrial Ca(2+) transport is reduced in HT, and tolerance t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc., publishers
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918869/ https://www.ncbi.nlm.nih.gov/pubmed/31456501 http://dx.doi.org/10.1089/thy.2018.0668 |