Changes in the Stoichiometry of Uniplex Decrease Mitochondrial Calcium Overload and Contribute to Tolerance of Cardiac Ischemia/Reperfusion Injury in Hypothyroidism

Background: Thyroid hormone status in hypothyroidism (HT) downregulates key elements in Ca(2+) handling within the heart, reducing contractility, impairing the basal energetic balance, and increasing the risk of cardiovascular disease. Mitochondrial Ca(2+) transport is reduced in HT, and tolerance t...

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Detalles Bibliográficos
Autores principales: Chapoy-Villanueva, Héctor, Silva-Platas, Christian, Gutiérrez-Rodríguez, Ana K., García, Noemí, Acuña-Morin, Edgar, Elizondo-Montemayor, Leticia, Oropeza-Almazán, Yuriana, Aguilar-Saenz, Alejandro, García-Rivas, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Thyroid Dysfunction: Hypothyroidism, Thyrotoxicosis, and Thyroid Function Tests
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918869/
https://www.ncbi.nlm.nih.gov/pubmed/31456501
http://dx.doi.org/10.1089/thy.2018.0668

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