NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies

BACKGROUND: Human hepatocyte in vitro cell culture systems are important models for drug development and toxicology studies in the context of liver xenobiotic metabolism. Often, such culture systems are used to elucidate the biotransformation of xenobiotics or drugs and further investigate drug and...

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Detalles Bibliográficos
Autores principales: Schulz, Christian, Kammerer, Sarah, Küpper, Jan-Heiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918903/
https://www.ncbi.nlm.nih.gov/pubmed/31561354
http://dx.doi.org/10.3233/CH-199226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918903/
https://www.ncbi.nlm.nih.gov/pubmed/31561354
http://dx.doi.org/10.3233/CH-199226

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