Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products

The amyloid-β protein precursor (AβPP) is critical in the pathophysiology of Alzheimer’s disease (AD), since two-step proteolytic processing of AβPP generates the neurotoxic amyloid-β peptide (Aβ). We developed a dual fluorescence labeling system to study the exact subcellular location of γ-secretas...

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Detalles Bibliográficos
Autores principales: van Husen, Lea S., Schedin-Weiss, Sophia, Trung, Minh Nguyen, Kazmi, Manija A., Winblad, Bengt, Sakmar, Thomas P., Elsässer, Simon J., Tjernberg, Lars O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918917/
https://www.ncbi.nlm.nih.gov/pubmed/31609694
http://dx.doi.org/10.3233/JAD-190898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918917/
https://www.ncbi.nlm.nih.gov/pubmed/31609694
http://dx.doi.org/10.3233/JAD-190898

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