Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

Doxorubicin- (DOX-) induced cardiotoxicity is associated with oxidative stress and cardiomyocyte apoptosis. The adaptor protein p66Shc regulates the cellular redox status and determines cell susceptibility to apoptosis. This study is aimed at investigating the involvement of sirtuin 1- (SIRT1-) medi...

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Detalles Bibliográficos
Autores principales: Wu, Yan-Zhao, Zhang, Lan, Wu, Zi-Xiao, Shan, Tong-tong, Xiong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918936/
https://www.ncbi.nlm.nih.gov/pubmed/31885776
http://dx.doi.org/10.1155/2019/2150394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918936/
https://www.ncbi.nlm.nih.gov/pubmed/31885776
http://dx.doi.org/10.1155/2019/2150394

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