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Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway
Doxorubicin- (DOX-) induced cardiotoxicity is associated with oxidative stress and cardiomyocyte apoptosis. The adaptor protein p66Shc regulates the cellular redox status and determines cell susceptibility to apoptosis. This study is aimed at investigating the involvement of sirtuin 1- (SIRT1-) medi...
Autores principales: | Wu, Yan-Zhao, Zhang, Lan, Wu, Zi-Xiao, Shan, Tong-tong, Xiong, Chen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918936/ https://www.ncbi.nlm.nih.gov/pubmed/31885776 http://dx.doi.org/10.1155/2019/2150394 |
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