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CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods

CRISPR-Cas9 has quickly become the method of choice for genome editing, with multiple publications describing technical advances and novel applications. It has been widely adopted as a tool for basic research and has significant translational and clinical potential. However, its usage has outpaced t...

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Detalles Bibliográficos
Autores principales: Rayner, Emily, Durin, Mary-Anne, Thomas, Rachael, Moralli, Daniela, O'Cathail, Sean M., Tomlinson, Ian, Green, Catherine M., Lewis, Annabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919265/
https://www.ncbi.nlm.nih.gov/pubmed/31742432
http://dx.doi.org/10.1089/crispr.2019.0006