Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease

In Alzheimer’s disease (AD), spliceosomal proteins with critical roles in RNA processing aberrantly aggregate and mislocalize to Tau neurofibrillary tangles. We test the hypothesis that Tau-spliceosome interactions disrupt pre-mRNA splicing in AD. In human postmortem brain with AD pathology, Tau coi...

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Detalles Bibliográficos
Autores principales: Hsieh, Yi-Chen, Guo, Caiwei, Yalamanchili, Hari K., Abreha, Measho, Al-Ouran, Rami, Li, Yarong, Dammer, Eric B., Lah, James J., Levey, Allan I., Bennett, David A., De Jager, Philip L., Seyfried, Nicholas T., Liu, Zhandong, Shulman, Joshua M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919331/
https://www.ncbi.nlm.nih.gov/pubmed/31597093
http://dx.doi.org/10.1016/j.celrep.2019.08.104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919331/
https://www.ncbi.nlm.nih.gov/pubmed/31597093
http://dx.doi.org/10.1016/j.celrep.2019.08.104

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