Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule

The drug-like molecule PF-06446846 (PF846) binds the human ribosome and selectively blocks the translation of a small number of proteins by an unknown mechanism. In structures of PF846-stalled human ribosome nascent chain complexes, PF846 binds in the ribosome exit tunnel in a eukaryotic-specific po...

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Detalles Bibliográficos
Autores principales: Li, Wenfei, Ward, Fred R., McClure, Kim F., Tsai-Lan Chang, Stacey, Montabana, Elizabeth, Liras, Spiros, Dullea, Robert G., Cate, Jamie H. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919564/
https://www.ncbi.nlm.nih.gov/pubmed/31160784
http://dx.doi.org/10.1038/s41594-019-0236-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919564/
https://www.ncbi.nlm.nih.gov/pubmed/31160784
http://dx.doi.org/10.1038/s41594-019-0236-8

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