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Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
The drug-like molecule PF-06446846 (PF846) binds the human ribosome and selectively blocks the translation of a small number of proteins by an unknown mechanism. In structures of PF846-stalled human ribosome nascent chain complexes, PF846 binds in the ribosome exit tunnel in a eukaryotic-specific po...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919564/ https://www.ncbi.nlm.nih.gov/pubmed/31160784 http://dx.doi.org/10.1038/s41594-019-0236-8 |