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Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination

Termination of DNA replication occurs when two replication forks converge upon the same stretch of DNA. Resolution of topological stress by topoisomerases is crucial for fork convergence in bacteria and viruses, but it is unclear whether similar mechanisms operate during vertebrate termination. Usin...

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Detalles Bibliográficos
Autores principales: Heintzman, Darren R., Campos, Lillian V., Byl, Jo Ann W., Osheroff, Neil, Dewar, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919565/
https://www.ncbi.nlm.nih.gov/pubmed/31597101
http://dx.doi.org/10.1016/j.celrep.2019.08.097