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Inferring reaction network structure from single-cell, multiplex data, using toric systems theory

The goal of many single-cell studies on eukaryotic cells is to gain insight into the biochemical reactions that control cell fate and state. In this paper we introduce the concept of Effective Stoichiometric Spaces (ESS) to guide the reconstruction of biochemical networks from multiplexed, fixed tim...

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Detalles Bibliográficos
Autores principales: Wang, Shu, Lin, Jia-Ren, Sontag, Eduardo D., Sorger, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919632/
https://www.ncbi.nlm.nih.gov/pubmed/31809500
http://dx.doi.org/10.1371/journal.pcbi.1007311