Cargando…
Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin—talin/α-catenin linkages
The vinculin-mediated mechanosensing requires establishment of stable mechanical linkages between vinculin to integrin at focal adhesions and to cadherins at adherens junctions through associations with the respective adaptor proteins talin and α-catenin. However, the mechanical stability of these c...
Autores principales: | Le, Shimin, Yu, Miao, Yan, Jie |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920023/ https://www.ncbi.nlm.nih.gov/pubmed/31897422 http://dx.doi.org/10.1126/sciadv.aav2720 |
Ejemplares similares
-
Mechanical stability of αT-catenin and its activation by force for vinculin binding
por: Pang, Si Ming, et al.
Publicado: (2019) -
Allosteric activation of vinculin by talin
por: Franz, Florian, et al.
Publicado: (2023) -
Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation
por: Yao, Mingxi, et al.
Publicado: (2014) -
Vinculin controls talin engagement with the actomyosin machinery
por: Atherton, Paul, et al.
Publicado: (2015) -
Vinculin controls focal adhesion formation by direct interactions with talin and actin
por: Humphries, Jonathan D., et al.
Publicado: (2007)