Cargando…

Pitfalls and solutions of the fully-automated radiosynthesis of [(11)C]metoclopramide

BACKGROUND: [(11)C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [(11)C]metoclopramide or other (11)C-labelled radiotracers, therefore al...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pichler, Verena, Ozenil, Marius, Bamminger, Karsten, Vraka, Chrysoula, Hacker, Marcus, Langer, Oliver, Wadsak, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920278/ https://www.ncbi.nlm.nih.gov/pubmed/31853677 http://dx.doi.org/10.1186/s41181-019-0083-2

Ejemplares similares

On the Road towards Small-Molecule Programmed Cell Death 1 Ligand 1 Positron Emission Tomography Tracers: A Ligand-Based Drug Design Approach
por: Bamminger, Karsten, et al.
Publicado: (2023)

Human Biodistribution and Radiation Dosimetry of the P-Glycoprotein Radiotracer [(11)C]Metoclopramide
por: Bauer, Martin, et al.
Publicado: (2021)

Synthesis, Biological, and Computational Evaluation of Antagonistic, Chiral Hydrobenzoin Esters of Arecaidine Targeting mAChR M1
por: Ozenil, Marius, et al.
Publicado: (2020)

Unexpected scaffold rearrangement product of pirenzepine found in commercial samples
por: Ozenil, Marius, et al.
Publicado: (2021)

Parameter evaluation and fully-automated radiosynthesis of [(11)C]harmine for imaging of MAO-A for clinical trials
por: Philippe, C., et al.
Publicado: (2015)

Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects
por: Bauer, Martin, et al.
Publicado: (2020)

Radiosynthesis and first preclinical evaluation of the novel norepinephrine transporter pet-ligand [(11)C]ME@HAPTHI
por: Rami-Mark, Christina, et al.
Publicado: (2015)

Update on PET Tracer Development for Muscarinic Acetylcholine Receptors
por: Ozenil, Marius, et al.
Publicado: (2021)

Design, Synthesis, and Biological Evaluation of 4,4’-Difluorobenzhydrol Carbamates as Selective M(1) Antagonists
por: Kilian, Jonas, et al.
Publicado: (2022)

Comparison of fully-automated radiosyntheses of [(11)C]erlotinib for preclinical and clinical use starting from in target produced [(11)C]CO(2) or [(11)C]CH(4)
por: Philippe, Cécile, et al.
Publicado: (2018)

Optimization of the Automated Synthesis of [(11)C]mHED—Administered and Apparent Molar Activities
por: Vraka, Chrysoula, et al.
Publicado: (2019)

Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi
por: Pacelli, Anna, et al.
Publicado: (2022)

Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs
por: Kilian, Jonas, et al.
Publicado: (2022)

Simultaneous radiomethylation of [(11)C]harmine and [(11)C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual
por: Vraka, Chrysoula, et al.
Publicado: (2022)

Fully automated radiosynthesis of [(68)Ga]Ga-FAPI-46 with cyclotron produced gallium
por: Rosenberg, Adam J., et al.
Publicado: (2023)

Improved Automated Radiosynthesis of [(11)C]PBR28
por: Solingapuram Sai, Kiran Kumar, et al.
Publicado: (2015)

SNAPshots of the MCHR1: a Comparison Between the PET-Tracers [(18)F]FE@SNAP and [(11)C]SNAP-7941
por: Philippe, Cécile, et al.
Publicado: (2018)

Automated One-pot Radiosynthesis of [(11)C]S-adenosyl Methionine
por: Zoppolo, Florencia, et al.
Publicado: (2017)

Fully-automated radiosynthesis of the amyloid tracer [(11)C] PiB via direct [(11)C]CO(2) fixation-reduction
por: Buccino, Pablo, et al.
Publicado: (2019)

[(18)F]FMeNER-D2: Reliable fully-automated synthesis for visualization of the norepinephrine transporter
por: Rami-Mark, Christina, et al.
Publicado: (2013)

Prediction of response and survival after standardized treatment with 7400 MBq (177)Lu-PSMA-617 every 4 weeks in patients with metastatic castration-resistant prostate cancer
por: Rasul, Sazan, et al.
Publicado: (2020)

GMP-compliant fully automated radiosynthesis of [(18)F]FEPPA for PET/MRI imaging of regional brain TSPO expression
por: Chang, Chi-Wei, et al.
Publicado: (2021)

A practical fully automated radiosynthesis of [(18)F]Flurpiridaz on the module modular lab-pharmtracer without external purification
por: Eryilmaz, Kurtulus, et al.
Publicado: (2022)

Detection of sympathetic denervation defects in Fabry disease by hybrid [(11)C]meta-hydroxyephedrine positron emission tomography and cardiac magnetic resonance
por: Gatterer, Constantin, et al.
Publicado: (2023)

Correction: Pacelli et al. Fully Automated, High-Dose Radiosynthesis of [18F]PARPi. Pharmaceuticals 2022, 15, 865
por: Pacelli, Anna, et al.
Publicado: (2023)

Assessment of sympathetic reinnervation after cardiac transplantation using hybrid cardiac PET/MRI: A pilot study
por: Beitzke, Dietrich, et al.
Publicado: (2019)

An efficient preparation of labelling precursor of [(11)C]L-deprenyl-D(2) and automated radiosynthesis
por: Zirbesegger, Kevin, et al.
Publicado: (2017)

Automated radiosynthesis of [(11)C]UCB‐J for imaging synaptic density by positron emission tomography
por: Milicevic Sephton, Selena, et al.
Publicado: (2020)

Serotonin Transporter Binding in the Human Brain After Pharmacological Challenge Measured Using PET and PET/MR
por: Silberbauer, Leo R., et al.
Publicado: (2019)

Robust and Facile Automated Radiosynthesis of [(18)F]FSPG on the GE FASTlab
por: Edwards, Richard, et al.
Publicado: (2021)

A simple and efficient automated microvolume radiosynthesis of [(18)F]Florbetaben
por: Lisova, Ksenia, et al.
Publicado: (2020)

Radiosynthesis of [(11)C]SNAP-7941—the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1)
por: Philippe, C., et al.
Publicado: (2012)

Automation of the Radiosynthesis of Six Different (18)F-labeled radiotracers on the AllinOne
por: Li, Shihong, et al.
Publicado: (2016)

Development and evaluation of a rapid analysis for HEPES determination in (68)Ga-radiotracers
por: Pfaff, Sarah, et al.
Publicado: (2018)

Radiosynthesis and reactivity of N-[(11)C]methyl carbamoylimidazole
por: Kadirvel, Manikandan, et al.
Publicado: (2018)

Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[(11)C]Me-NB1
por: Rischka, Lucas, et al.
Publicado: (2022)

Effect of MAOA DNA Methylation on Human in Vivo Protein Expression Measured by [(11)C]harmine Positron Emission Tomography
por: Handschuh, Patricia A, et al.
Publicado: (2022)

Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated (18)F-trifluoromethylation procedure
por: King, Alice, et al.
Publicado: (2018)

Automated Radiosynthesis, Quality Control, and Biodistribution of Ga-68 Pentixafor: First Indian Experience
por: Watts, Ankit, et al.
Publicado: (2021)

If It Works, Don’t Touch It? A Cell-Based Approach to Studying 2-[(18)F]FDG Metabolism
por: Klebermass, Eva-Maria, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r3dgc9pfj8093dqkpsdtb23jrc