The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1

OBJECTIVES: The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted from intestinal L-cells upon nutrient intake. While recent evidence has shown that GLP-1 is released in a circadian manner in rats, whether this occurs in mice and if this pattern is regulated by the circadian clock remain...

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Detalles Bibliográficos
Autores principales: Biancolin, Andrew D., Martchenko, Alexandre, Mitova, Emilia, Gurges, Patrick, Michalchyshyn, Everan, Chalmers, Jennifer A., Doria, Alessandro, Mychaleckyj, Josyf C., Adriaenssens, Alice E., Reimann, Frank, Gribble, Fiona M., Gil-Lozano, Manuel, Cox, Brian J., Brubaker, Patricia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920326/
https://www.ncbi.nlm.nih.gov/pubmed/31918914
http://dx.doi.org/10.1016/j.molmet.2019.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920326/
https://www.ncbi.nlm.nih.gov/pubmed/31918914
http://dx.doi.org/10.1016/j.molmet.2019.11.004

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