Cargando…
The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1
OBJECTIVES: The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted from intestinal L-cells upon nutrient intake. While recent evidence has shown that GLP-1 is released in a circadian manner in rats, whether this occurs in mice and if this pattern is regulated by the circadian clock remain...
Autores principales: | Biancolin, Andrew D., Martchenko, Alexandre, Mitova, Emilia, Gurges, Patrick, Michalchyshyn, Everan, Chalmers, Jennifer A., Doria, Alessandro, Mychaleckyj, Josyf C., Adriaenssens, Alice E., Reimann, Frank, Gribble, Fiona M., Gil-Lozano, Manuel, Cox, Brian J., Brubaker, Patricia L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920326/ https://www.ncbi.nlm.nih.gov/pubmed/31918914 http://dx.doi.org/10.1016/j.molmet.2019.11.004 |
Ejemplares similares
-
Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion
por: Martchenko, Alexandre, et al.
Publicado: (2022) -
L-cell Arntl is required for rhythmic glucagon-like peptide-1 secretion and maintenance of intestinal homeostasis
por: Martchenko, Sarah E., et al.
Publicado: (2021) -
Essential Role of Syntaxin-Binding Protein-1 in the Regulation of Glucagon-Like Peptide-1 Secretion
por: Campbell, Jhenielle R, et al.
Publicado: (2020) -
SUN-LB018 Role of BMAL1 in Western Diet-Induced Disruption of Circadian Hypothalamic Feeding Neuropeptides
por: Clemenzi, Matthew, et al.
Publicado: (2019) -
Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion
por: Parker, H. E., et al.
Publicado: (2012)