CD8(+) T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome

Neuroinflammation is often associated with blood-brain-barrier dysfunction, which contributes to neurological tissue damage. Here, we reveal the pathophysiology of Susac syndrome (SuS), an enigmatic neuroinflammatory disease with central nervous system (CNS) endotheliopathy. By investigating immune...

Descripción completa

Detalles Bibliográficos
Autores principales: Gross, Catharina C., Meyer, Céline, Bhatia, Urvashi, Yshii, Lidia, Kleffner, Ilka, Bauer, Jan, Tröscher, Anna R., Schulte-Mecklenbeck, Andreas, Herich, Sebastian, Schneider-Hohendorf, Tilman, Plate, Henrike, Kuhlmann, Tanja, Schwaninger, Markus, Brück, Wolfgang, Pawlitzki, Marc, Laplaud, David-Axel, Loussouarn, Delphine, Parratt, John, Barnett, Michael, Buckland, Michael E., Hardy, Todd A., Reddel, Stephen W., Ringelstein, Marius, Dörr, Jan, Wildemann, Brigitte, Kraemer, Markus, Lassmann, Hans, Höftberger, Romana, Beltrán, Eduardo, Dornmair, Klaus, Schwab, Nicholas, Klotz, Luisa, Meuth, Sven G., Martin-Blondel, Guillaume, Wiendl, Heinz, Liblau, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920411/
https://www.ncbi.nlm.nih.gov/pubmed/31852955
http://dx.doi.org/10.1038/s41467-019-13593-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920411/
https://www.ncbi.nlm.nih.gov/pubmed/31852955
http://dx.doi.org/10.1038/s41467-019-13593-5

Ejemplares similares