Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis

DNA damage and DNA damage response (DDR) pathways in β-cells have received little attention especially in the context of type-2 diabetes. We postulate that p21 plays a key role in DDR by preventing apoptosis, associated through its overexpression triggered by DNA stand breaks (DSBs). Our results sho...

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Detalles Bibliográficos
Autores principales: Tay, Vanessa S. Y., Devaraj, Surabhi, Koh, Tracy, Ke, Guo, Crasta, Karen C., Ali, Yusuf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920453/
https://www.ncbi.nlm.nih.gov/pubmed/31852915
http://dx.doi.org/10.1038/s41598-019-54554-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920453/
https://www.ncbi.nlm.nih.gov/pubmed/31852915
http://dx.doi.org/10.1038/s41598-019-54554-8

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