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Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis
DNA damage and DNA damage response (DDR) pathways in β-cells have received little attention especially in the context of type-2 diabetes. We postulate that p21 plays a key role in DDR by preventing apoptosis, associated through its overexpression triggered by DNA stand breaks (DSBs). Our results sho...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920453/ https://www.ncbi.nlm.nih.gov/pubmed/31852915 http://dx.doi.org/10.1038/s41598-019-54554-8 |