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Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice

Kynurenic acid (KYNA), a glial-derived metabolite of tryptophan metabolism, is an antagonist of the alpha 7 nicotinic acetylcholine receptor and the glycine-binding site of N-methyl-d-aspartate (NMDA) receptors. Kynurenic acid levels are increased in both the brain and cerebrospinal fluid of several...

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Detalles Bibliográficos
Autores principales: Peyton, Lee, Oliveros, Alfredo, Tufvesson-Alm, Maximilian, Schwieler, Lilly, Starski, Phillip, Engberg, Göran, Erhardt, Sopie, Choi, Doo-Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920585/
https://www.ncbi.nlm.nih.gov/pubmed/31896932
http://dx.doi.org/10.1177/1178646919891169