Cargando…

Highly Water-Soluble Solid Dispersions of Honokiol: Preparation, Solubility, and Bioavailability Studies and Anti-Tumor Activity Evaluation

Honokiol (HK), a well-tolerated natural product, has many multiple pharmacological activities. However, its poor water solubility and low bioavailability limit its clinical application and development. The aim of this research was to prepare the solid dispersion (SD) formulation of honokiol (HK) wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Li, Wu, Weiwei, Wang, Lingling, Wang, Lu, Zhao, Xiuhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920775/ https://www.ncbi.nlm.nih.gov/pubmed/31683964 http://dx.doi.org/10.3390/pharmaceutics11110573

Ejemplares similares

Enhanced Solubility and Bioavailability of Apigenin via Preparation of Solid Dispersions of Mesoporous Silica Nanoparticles
por: Huang, Yannian, et al.
Publicado: (2019)

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs
por: Tran, Thao T.D., et al.
Publicado: (2020)

Spray Congealing: An Emerging Technology to Prepare Solid Dispersions with Enhanced Oral Bioavailability of Poorly Water Soluble Drugs
por: Bertoni, Serena, et al.
Publicado: (2019)

Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and bioavailability
por: Wang, Yi, et al.
Publicado: (2022)

Mechanochemical preparation of chrysomycin A self-micelle solid dispersion with improved solubility and enhanced oral bioavailability
por: Xu, Zhuomin, et al.
Publicado: (2021)

Improvement in solubility of poor water-soluble drugs by solid dispersion
por: Sareen, Swati, et al.
Publicado: (2012)

Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation techniques, current marketed scenario and patents
por: Alshehri, Sultan, et al.
Publicado: (2020)

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs
por: Zhang, Xingwang, et al.
Publicado: (2018)

Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility, Dissolution, and Bioavailability in Rats
por: Cho, Hyun-Jong, et al.
Publicado: (2017)

Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan
por: Giri, Bhupendra Raj, et al.
Publicado: (2021)

Exploring the Solubility and Bioavailability of Sodium Salt and Its Free Acid Solid Dispersions of Dolutegravir
por: Yarlagadda, Dani Lakshman, et al.
Publicado: (2023)

Preparation and Evaluation of Amorphous Solid Dispersions for Enhancing Luteolin’s Solubility in Simulated Saliva
por: Koromili, Maria, et al.
Publicado: (2022)

Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability
por: Lee, Juseung, et al.
Publicado: (2023)

Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion
por: Altamimi, Mohammad A., et al.
Publicado: (2019)

Preparation of honokiol nanoparticles by liquid antisolvent precipitation technique, characterization, pharmacokinetics, and evaluation of inhibitory effect on HepG2 cells
por: Wu, Weiwei, et al.
Publicado: (2018)

Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent
por: Yang, Qilei, et al.
Publicado: (2020)

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs
por: Tran, Thao T. D., et al.
Publicado: (2020)

Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe
por: Rashid, Rehmana, et al.
Publicado: (2015)

Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability
por: Liu, Pei, et al.
Publicado: (2020)

Solubility, Antioxidation, and Oral Bioavailability Improvement of Mangiferin Microparticles Prepared Using the Supercritical Antisolvent Method
por: Liu, Mengran, et al.
Publicado: (2020)

Solubility Enhancement of a Poorly Water Soluble Drug by Forming Solid Dispersions using Mechanochemical Activation
por: Rojas-Oviedo, I., et al.
Publicado: (2012)

A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs
por: Tekade, Avinash Ramrao, et al.
Publicado: (2020)

Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion
por: Chen, Bing, et al.
Publicado: (2020)

Sustained-Release Solid Dispersion of High-Melting-Point and Insoluble Resveratrol Prepared through Hot Melt Extrusion to Improve Its Solubility and Bioavailability
por: Zhu, Wenjing, et al.
Publicado: (2021)

Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability
por: Jiang, Yihua, et al.
Publicado: (2022)

Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs
por: Tran, Phuong, et al.
Publicado: (2019)

Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques
por: Abdullah Ali, Hezha, et al.
Publicado: (2022)

Solubility Improvement of Progesterone from Solid Dispersions Prepared by Solvent Evaporation and Co-milling
por: Chen, Xing, et al.
Publicado: (2020)

Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation, optimization and physiologically based pharmacokinetic modeling
por: Fouad, Shahinaze A., et al.
Publicado: (2021)

Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability
por: Lin, Hong-Liang, et al.
Publicado: (2021)

Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate
por: Yousaf, Abid Mehmood, et al.
Publicado: (2016)

Preparation of Nanocrystals for Insoluble Drugs by Top-Down Nanotechnology with Improved Solubility and Bioavailability
por: Zhang, Xun, et al.
Publicado: (2020)

Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability
por: Han, Fei, et al.
Publicado: (2019)

Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method
por: Yang, Gang, et al.
Publicado: (2020)

Solubility and Physical Stability Enhancement of Loratadine by Preparation of Co-Amorphous Solid Dispersion with Chlorpheniramine and Polyvinylpyrrolidone
por: Suknuntha, Krit, et al.
Publicado: (2023)

Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods
por: Školáková, Tereza, et al.
Publicado: (2019)

Water-Soluble Metalated Covalent Organic Nanobelts with Improved Bioavailability for Protein Transportation
por: Kong, Weifu, et al.
Publicado: (2018)

Construction, characterization, and bioavailability evaluation of honokiol-loaded porous starch by melting method without any solvent
por: Wu, Weiwei, et al.
Publicado: (2021)

Solubility and Bioavailability Enhancement of Oridonin: A Review
por: Zhang, Yuanyuan, et al.
Publicado: (2020)

Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo
por: Xi, Ziyue, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_prhgb2c82p9mn9j3gpej0obdlh