Dynamic DNA Energy Landscapes and Substrate Complexity in Triplet Repeat Expansion and DNA Repair

DNA repeat domains implicated in DNA expansion diseases exhibit complex conformational and energy landscapes that impact biological outcomes. These landscapes include ensembles of entropically driven positional interchanges between isoenergetic, isomeric looped states referred to as rollamers. Here,...

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Detalles Bibliográficos
Autores principales: Völker, Jens, Plum, G. Eric, Gindikin, Vera, Breslauer, Kenneth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920812/
https://www.ncbi.nlm.nih.gov/pubmed/31698848
http://dx.doi.org/10.3390/biom9110709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920812/
https://www.ncbi.nlm.nih.gov/pubmed/31698848
http://dx.doi.org/10.3390/biom9110709

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