The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance

The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs) itself contributes to the drug resistance in...

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Detalles Bibliográficos
Autores principales: Ruzickova, Eliska, Skoupa, Nikola, Dolezel, Petr, Smith, Dennis A., Mlejnek, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921012/
https://www.ncbi.nlm.nih.gov/pubmed/31683643
http://dx.doi.org/10.3390/biom9110675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921012/
https://www.ncbi.nlm.nih.gov/pubmed/31683643
http://dx.doi.org/10.3390/biom9110675

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