The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches...

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Detalles Bibliográficos
Autores principales: Chang, Hyeyoun, Cai, Zhenying, Roberts, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921025/
https://www.ncbi.nlm.nih.gov/pubmed/31703360
http://dx.doi.org/10.3390/biom9110713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921025/
https://www.ncbi.nlm.nih.gov/pubmed/31703360
http://dx.doi.org/10.3390/biom9110713

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