The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches...

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Detalles Bibliográficos
Autores principales: Chang, Hyeyoun, Cai, Zhenying, Roberts, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921025/
https://www.ncbi.nlm.nih.gov/pubmed/31703360
http://dx.doi.org/10.3390/biom9110713
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author Chang, Hyeyoun
Cai, Zhenying
Roberts, Thomas M.
author_facet Chang, Hyeyoun
Cai, Zhenying
Roberts, Thomas M.
author_sort Chang, Hyeyoun
collection PubMed
description In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches for patients with PTEN-null tumors.
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spelling pubmed-69210252019-12-24 The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities Chang, Hyeyoun Cai, Zhenying Roberts, Thomas M. Biomolecules Review In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches for patients with PTEN-null tumors. MDPI 2019-11-07 /pmc/articles/PMC6921025/ /pubmed/31703360 http://dx.doi.org/10.3390/biom9110713 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chang, Hyeyoun
Cai, Zhenying
Roberts, Thomas M.
The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
title The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
title_full The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
title_fullStr The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
title_full_unstemmed The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
title_short The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
title_sort mechanisms underlying pten loss in human tumors suggest potential therapeutic opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921025/
https://www.ncbi.nlm.nih.gov/pubmed/31703360
http://dx.doi.org/10.3390/biom9110713
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