Computational Modeling Explains the Multi Sterol Ligand Specificity of the N-Terminal Domain of Niemann–Pick C1-Like 1 Protein

[Image: see text] Niemann–Pick C1 like 1 (NPC1L1) is a sterol transporter expressed in the apical membrane of enterocytes and hepatocytes. NPC1L1 resembles the lysosomal NPC1 protein including an N-terminal domain (NTD), which binds a variety of sterols. The molecular mechanisms underlying this mult...

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Detalles Bibliográficos
Autores principales: Poongavanam, Vasanthanathan, Kongsted, Jacob, Wüstner, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921270/
https://www.ncbi.nlm.nih.gov/pubmed/31867479
http://dx.doi.org/10.1021/acsomega.9b01668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921270/
https://www.ncbi.nlm.nih.gov/pubmed/31867479
http://dx.doi.org/10.1021/acsomega.9b01668

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