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Early active immunization with Aβ(3–10)-KLH vaccine reduces tau phosphorylation in the hippocampus and protects cognition of mice

Active and passive anti-Aβ immunotherapies have successfully been used for the prevention and treatment of Alzheimer’s disease animal models. However, clinical use of these immunotherapies is not effective, because the vaccination is administered too late. At 1 month of age, 100 μL of Aβ(3–10)-KLH p...

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Detalles Bibliográficos
Autores principales: Wang, Jin-Chun, Zhu, Kun, Zhang, Hui-Yi, Wang, Guo-Qing, Liu, Hui-Ying, Cao, Yun-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921334/
https://www.ncbi.nlm.nih.gov/pubmed/31571664
http://dx.doi.org/10.4103/1673-5374.266061