Synthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activity

[Image: see text] A novel macrocyclic construct consisting of a pyrazolopyrimidine scaffold concatenated to a benzene ring through two triazoles has been developed to investigate uncharted chemical space with bioactive potential. The 18-atom macrocycle was assembled via a double copper-catalyzed alk...

Descripción completa

Detalles Bibliográficos
Autores principales: Cruz-López, Olga, Temps, Carolin, Longo, Beatrice, Myers, Samuel H., Franco-Montalban, Francisco, Unciti-Broceta, Asier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921642/
https://www.ncbi.nlm.nih.gov/pubmed/31867559
http://dx.doi.org/10.1021/acsomega.9b03525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921642/
https://www.ncbi.nlm.nih.gov/pubmed/31867559
http://dx.doi.org/10.1021/acsomega.9b03525

Ejemplares similares