Cargando…
Synthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activity
[Image: see text] A novel macrocyclic construct consisting of a pyrazolopyrimidine scaffold concatenated to a benzene ring through two triazoles has been developed to investigate uncharted chemical space with bioactive potential. The 18-atom macrocycle was assembled via a double copper-catalyzed alk...
Autores principales: | Cruz-López, Olga, Temps, Carolin, Longo, Beatrice, Myers, Samuel H., Franco-Montalban, Francisco, Unciti-Broceta, Asier |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921642/ https://www.ncbi.nlm.nih.gov/pubmed/31867559 http://dx.doi.org/10.1021/acsomega.9b03525 |
Ejemplares similares
-
Development of
Potent Inhibitors of Receptor Tyrosine
Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening
por: Myers, Samuel H., et al.
Publicado: (2018) -
Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold
por: Baillache, Daniel J., et al.
Publicado: (2020) -
Targeted Molecular Construct for Bioorthogonal Theranostics
of PD-L1-Expressing Cancer Cells
por: Chow, Shiao Y., et al.
Publicado: (2022) -
Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy
por: Weiss, Jason T., et al.
Publicado: (2015) -
Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway
por: Valero, Teresa, et al.
Publicado: (2020)