Ligand-induced conformational selection predicts the selectivity of cysteine protease inhibitors

Cruzain, a cysteine protease of Trypanosoma cruzi, is a validated target for the treatment of Chagas disease. Due to its high similarity in three-dimensional structure with human cathepsins and their sequence identity above 70% in the active site regions, identifying potent but selective cruzain inh...

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Detalles Bibliográficos
Autores principales: Sartori, Geraldo Rodrigues, Leitão, Andrei, Montanari, Carlos A., Laughton, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922342/
https://www.ncbi.nlm.nih.gov/pubmed/31856175
http://dx.doi.org/10.1371/journal.pone.0222055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922342/
https://www.ncbi.nlm.nih.gov/pubmed/31856175
http://dx.doi.org/10.1371/journal.pone.0222055

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