De novo design of a homo-trimeric amantadine-binding protein

The computational design of a symmetric protein homo-oligomer that binds a symmetry-matched small molecule larger than a metal ion has not yet been achieved. We used de novo protein design to create a homo-trimeric protein that binds the C(3) symmetric small molecule drug amantadine with each protei...

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Detalles Bibliográficos
Autores principales: Park, Jooyoung, Selvaraj, Brinda, McShan, Andrew C, Boyken, Scott E, Wei, Kathy Y, Oberdorfer, Gustav, DeGrado, William, Sgourakis, Nikolaos G, Cuneo, Matthew J, Myles, Dean AA, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922598/
https://www.ncbi.nlm.nih.gov/pubmed/31854299
http://dx.doi.org/10.7554/eLife.47839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922598/
https://www.ncbi.nlm.nih.gov/pubmed/31854299
http://dx.doi.org/10.7554/eLife.47839

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