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De novo design of a homo-trimeric amantadine-binding protein
The computational design of a symmetric protein homo-oligomer that binds a symmetry-matched small molecule larger than a metal ion has not yet been achieved. We used de novo protein design to create a homo-trimeric protein that binds the C(3) symmetric small molecule drug amantadine with each protei...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922598/ https://www.ncbi.nlm.nih.gov/pubmed/31854299 http://dx.doi.org/10.7554/eLife.47839 |