Cell adhesion to collagen promotes leukemia resistance to doxorubicin by reducing DNA damage through the inhibition of Rac1 activation

Chemoresistance is a major hurdle in anti-cancer therapy. Growing evidence indicates that integrin-mediated cell adhesion to extracellular matrix plays a major role in chemoresistance. However, the underlying mechanisms are not fully understood. We have previously shown that the collagen-binding int...

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Detalles Bibliográficos
Autores principales: Naci, Dalila, Berrazouane, Sofiane, Barabé, Frédéric, Aoudjit, Fawzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923425/
https://www.ncbi.nlm.nih.gov/pubmed/31857649
http://dx.doi.org/10.1038/s41598-019-55934-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923425/
https://www.ncbi.nlm.nih.gov/pubmed/31857649
http://dx.doi.org/10.1038/s41598-019-55934-w

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