Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys

A number of publications have described the use of adeno-associated virus (AAV) for the delivery of anti-HIV and anti-simian immunodeficiency virus (SIV) monoclonal antibodies (mAbs) to rhesus monkeys. Anti-drug antibodies (ADAs) have been frequently observed, and long-term AAV-mediated delivery has...

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Detalles Bibliográficos
Autores principales: Fuchs, Sebastian P., Martinez-Navio, José M., Rakasz, Eva G., Gao, Guangping, Desrosiers, Ronald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923507/
https://www.ncbi.nlm.nih.gov/pubmed/31890736
http://dx.doi.org/10.1016/j.omtm.2019.11.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923507/
https://www.ncbi.nlm.nih.gov/pubmed/31890736
http://dx.doi.org/10.1016/j.omtm.2019.11.010

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