KRAS4A Directly Regulates Hexokinase 1

The most frequently mutated oncogene in cancer is KRAS, which utilizes alternative fourth exons to generate two gene products, KRAS4A and KRAS4B, that differ only in their C-terminal membrane-targeting region (1). Because oncogenic mutations occur in exons 2 or 3, when KRAS is activated by mutation...

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Detalles Bibliográficos
Autores principales: Amendola, Caroline R., Mahaffey, James P., Parker, Seth J., Ahearn, Ian M., Chen, Wei-Ching, Zhou, Mo, Court, Helen, Shi, Jie, Mendoza, Sebastian L., Morten, Michael, Rothenberg, Eli, Gottlieb, Eyal, Wadghiri, Youssef Z., Possemato, Richard, Hubbard, Stevan R., Balmain, Allan, Kimmelman, Alec, Philips, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923592/
https://www.ncbi.nlm.nih.gov/pubmed/31827279
http://dx.doi.org/10.1038/s41586-019-1832-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923592/
https://www.ncbi.nlm.nih.gov/pubmed/31827279
http://dx.doi.org/10.1038/s41586-019-1832-9

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