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NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia

Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with severe long-term sequelae such as cerebral palsy, epilepsy and cognitive disabilities. Na(+)-K(+)-2Cl(–) cotransporters 1 (NKCC1) is dramatically upregulated after hypoxia-ischemia (HI), which aggravates brain edema and brain...

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Detalles Bibliográficos
Autores principales: Yang, Xing-Liang, Zeng, Meng-Liu, Shao, Lin, Jiang, Guang-Tong, Cheng, Jing-Jing, Chen, Tao-Xiang, Han, Song, Yin, Jun, Liu, Wan-Hong, He, Xiao-Hua, Peng, Bi-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923656/
https://www.ncbi.nlm.nih.gov/pubmed/31921851
http://dx.doi.org/10.3389/fcell.2019.00339