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Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice
BACKGROUND: Alzheimer’s disease (AD) is a fatal neurodegenerative disease. APOE4 is the greatest genetic risk factor for AD, increasing risk up to 15-fold compared to the common APOE3. Importantly, female (♀) APOE4 carriers have a greater risk for developing AD and an increased rate of cognitive dec...
Autores principales: | Maldonado Weng, Juan, Parikh, Ishita, Naqib, Ankur, York, Jason, Green, Stefan J., Estus, Steven, LaDu, Mary Jo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923910/ https://www.ncbi.nlm.nih.gov/pubmed/31861986 http://dx.doi.org/10.1186/s13024-019-0352-2 |
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