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Improved cell composition deconvolution method of bulk gene expression profiles to quantify subsets of immune cells

BACKGROUND: To facilitate the investigation of the pathogenic roles played by various immune cells in complex tissues such as tumors, a few computational methods for deconvoluting bulk gene expression profiles to predict cell composition have been created. However, available methods were usually dev...

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Detalles Bibliográficos
Autores principales: Chiu, Yen-Jung, Hsieh, Yi-Hsuan, Huang, Yen-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923925/
https://www.ncbi.nlm.nih.gov/pubmed/31856824
http://dx.doi.org/10.1186/s12920-019-0613-5