Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics

Fibroblast growth factor 2 (FGF2) plays important roles in tissue development and repair. Using heparan sulfates (HS)/heparin as a cofactor, FGF2 binds to FGF receptor (FGFR) and induces downstream signaling pathways, such as ERK pathway, that regulate cellular behavior. In most cell lines, FGF2 sig...

Descripción completa

Detalles Bibliográficos
Autores principales: Koledova, Zuzana, Sumbal, Jakub, Rabata, Anas, de La Bourdonnaye, Gabin, Chaloupkova, Radka, Hrdlickova, Barbara, Damborsky, Jiri, Stepankova, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924264/
https://www.ncbi.nlm.nih.gov/pubmed/31921844
http://dx.doi.org/10.3389/fcell.2019.00331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924264/
https://www.ncbi.nlm.nih.gov/pubmed/31921844
http://dx.doi.org/10.3389/fcell.2019.00331

Ejemplares similares