Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics

Fibroblast growth factor 2 (FGF2) plays important roles in tissue development and repair. Using heparan sulfates (HS)/heparin as a cofactor, FGF2 binds to FGF receptor (FGFR) and induces downstream signaling pathways, such as ERK pathway, that regulate cellular behavior. In most cell lines, FGF2 sig...

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Detalles Bibliográficos
Autores principales: Koledova, Zuzana, Sumbal, Jakub, Rabata, Anas, de La Bourdonnaye, Gabin, Chaloupkova, Radka, Hrdlickova, Barbara, Damborsky, Jiri, Stepankova, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924264/
https://www.ncbi.nlm.nih.gov/pubmed/31921844
http://dx.doi.org/10.3389/fcell.2019.00331

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